Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease
Identifieur interne : 000587 ( Main/Exploration ); précédent : 000586; suivant : 000588Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease
Auteurs : Abid Oueslati [Suisse, Canada] ; Blaise Lovisa [Suisse] ; John Perrin [Suisse] ; Georges Wagnières [Suisse] ; Hubert Van Den Bergh [Suisse] ; Yanik Tardy [Suisse] ; Hilal A. Lashuel [Suisse, Qatar]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Corpus Striatum (metabolism), Corpus Striatum (pathology), Corpus Striatum (radiation effects), Disease Models, Animal, Dopaminergic Neurons (metabolism), Dopaminergic Neurons (pathology), Dopaminergic Neurons (radiation effects), Female, Low-Level Light Therapy, Parkinson Disease (genetics), Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson Disease (radiotherapy), Rats, Rats, Sprague-Dawley, Substantia Nigra (metabolism), Substantia Nigra (pathology), Substantia Nigra (radiation effects).
- MESH :
- genetics : Parkinson Disease.
- metabolism : Corpus Striatum, Dopaminergic Neurons, Parkinson Disease, Substantia Nigra.
- pathology : Corpus Striatum, Dopaminergic Neurons, Parkinson Disease, Substantia Nigra.
- radiation effects : Corpus Striatum, Dopaminergic Neurons, Substantia Nigra.
- radiotherapy : Parkinson Disease.
- Animals, Disease Models, Animal, Female, Low-Level Light Therapy, Rats, Rats, Sprague-Dawley.
Abstract
Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including neurodegenerative disorders. In the present study, we report that chronic PMB treatment mitigates dopaminergic loss induced by unilateral overexpression of human α-synuclein (α-syn) in the substantia nigra of an AAV-based rat genetic model of Parkinson’s disease (PD). In this model, daily exposure of both sides of the rat’s head to 808-nm near-infrared light for 28 consecutive days alleviated α-syn-induced motor impairment, as assessed using the cylinder test. This treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. These beneficial effects were sustained for at least 6 weeks after discontinuing the treatment. Together, our data point to PBM as a possible therapeutic strategy for the treatment of PD and other related synucleinopathies.
Url:
DOI: 10.1371/journal.pone.0140880
PubMed: 26484876
PubMed Central: 4617694
Affiliations:
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Le document en format XML
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Moléculaire de l'Université Laval, Québec, G1V4G2</wicri:regionArea><wicri:noRegion>G1V4G2</wicri:noRegion></affiliation></author><author><name sortKey="Lovisa, Blaise" sort="Lovisa, Blaise" uniqKey="Lovisa B" first="Blaise" last="Lovisa">Blaise Lovisa</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Medos International Sàrl, a Johnson&Johnson company, Chemin Blanc 38, CH-2400, Le Locle, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Medos International Sàrl, a Johnson&Johnson company, Chemin Blanc 38, CH-2400, Le Locle</wicri:regionArea><wicri:noRegion>Le Locle</wicri:noRegion></affiliation></author><author><name sortKey="Perrin, John" sort="Perrin, John" uniqKey="Perrin J" first="John" last="Perrin">John Perrin</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Wagnieres, Georges" sort="Wagnieres, Georges" uniqKey="Wagnieres G" first="Georges" last="Wagnières">Georges Wagnières</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Van Den Bergh, Hubert" sort="Van Den Bergh, Hubert" uniqKey="Van Den Bergh H" first="Hubert" last="Van Den Bergh">Hubert Van Den Bergh</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Tardy, Yanik" sort="Tardy, Yanik" uniqKey="Tardy Y" first="Yanik" last="Tardy">Yanik Tardy</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Medos International Sàrl, a Johnson&Johnson company, Chemin Blanc 38, CH-2400, Le Locle, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Medos International Sàrl, a Johnson&Johnson company, Chemin Blanc 38, CH-2400, Le Locle</wicri:regionArea><wicri:noRegion>Le Locle</wicri:noRegion></affiliation></author><author><name sortKey="Lashuel, Hilal A" sort="Lashuel, Hilal A" uniqKey="Lashuel H" first="Hilal A." last="Lashuel">Hilal A. Lashuel</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), CH-1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, P.O. Box 5825, Doha, Qatar</addr-line></nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, P.O. Box 5825, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (pathology)</term><term>Corpus Striatum (radiation effects)</term><term>Disease Models, Animal</term><term>Dopaminergic Neurons (metabolism)</term><term>Dopaminergic Neurons (pathology)</term><term>Dopaminergic Neurons (radiation effects)</term><term>Female</term><term>Low-Level Light Therapy</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (radiotherapy)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (pathology)</term><term>Substantia Nigra (radiation effects)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Dopaminergic Neurons</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Dopaminergic Neurons</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Corpus Striatum</term><term>Dopaminergic Neurons</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Low-Level Light Therapy</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including neurodegenerative disorders. In the present study, we report that chronic PMB treatment mitigates dopaminergic loss induced by unilateral overexpression of human α-synuclein (α-syn) in the substantia nigra of an AAV-based rat genetic model of Parkinson’s disease (PD). In this model, daily exposure of both sides of the rat’s head to 808-nm near-infrared light for 28 consecutive days alleviated α-syn-induced motor impairment, as assessed using the cylinder test. This treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. These beneficial effects were sustained for at least 6 weeks after discontinuing the treatment. Together, our data point to PBM as a possible therapeutic strategy for the treatment of PD and other related synucleinopathies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Obeso, Ja" uniqKey="Obeso J">JA Obeso</name></author><author><name sortKey="Rodriguez Oroz, Mc" uniqKey="Rodriguez Oroz M">MC Rodriguez-Oroz</name></author><author><name sortKey="Goetz, Cg" uniqKey="Goetz C">CG Goetz</name></author><author><name sortKey="Marin, C" uniqKey="Marin C">C Marin</name></author><author><name sortKey="Kordower, Jh" uniqKey="Kordower J">JH Kordower</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dauer, W" uniqKey="Dauer W">W Dauer</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lashuel, Ha" uniqKey="Lashuel H">HA Lashuel</name></author><author><name sortKey="Overk, Cr" 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Whelan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trancikova, A" uniqKey="Trancikova A">A Trancikova</name></author><author><name sortKey="Tsika, E" uniqKey="Tsika E">E Tsika</name></author><author><name sortKey="Moore, Dj" uniqKey="Moore D">DJ Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mullin, S" uniqKey="Mullin S">S Mullin</name></author><author><name sortKey="Schapira, A" uniqKey="Schapira A">A Schapira</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Qatar</li><li>Suisse</li></country><region><li>Canton de Vaud</li></region><settlement><li>Lausanne</li></settlement></list><tree><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Oueslati, Abid" sort="Oueslati, Abid" uniqKey="Oueslati A" first="Abid" last="Oueslati">Abid Oueslati</name></region><name sortKey="Lashuel, Hilal A" sort="Lashuel, Hilal A" uniqKey="Lashuel H" first="Hilal A." last="Lashuel">Hilal A. Lashuel</name><name sortKey="Lovisa, Blaise" sort="Lovisa, Blaise" uniqKey="Lovisa B" first="Blaise" last="Lovisa">Blaise Lovisa</name><name sortKey="Lovisa, Blaise" sort="Lovisa, Blaise" uniqKey="Lovisa B" first="Blaise" last="Lovisa">Blaise Lovisa</name><name sortKey="Perrin, John" sort="Perrin, John" uniqKey="Perrin J" first="John" last="Perrin">John Perrin</name><name sortKey="Tardy, Yanik" sort="Tardy, Yanik" uniqKey="Tardy Y" first="Yanik" last="Tardy">Yanik Tardy</name><name sortKey="Van Den Bergh, Hubert" sort="Van Den Bergh, Hubert" uniqKey="Van Den Bergh H" first="Hubert" last="Van Den Bergh">Hubert Van Den Bergh</name><name sortKey="Wagnieres, Georges" sort="Wagnieres, Georges" uniqKey="Wagnieres G" first="Georges" last="Wagnières">Georges Wagnières</name></country><country name="Canada"><noRegion><name sortKey="Oueslati, Abid" sort="Oueslati, Abid" uniqKey="Oueslati A" first="Abid" last="Oueslati">Abid Oueslati</name></noRegion></country><country name="Qatar"><noRegion><name sortKey="Lashuel, Hilal A" sort="Lashuel, Hilal A" uniqKey="Lashuel H" first="Hilal A." last="Lashuel">Hilal A. 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